I just saw him in the season (and series) final of Boston Legal.
His character, Alan Shore, was married to William Shatner's Denny Crane, officiated by Supreme Court justice Antonin Scalia (it wasn't for sex).
That reminded me of an old VHS movie I have starring James Spader:
The Music of Chance.
It includes: James Spader, Mandy Patinkin, M. Emmet Walsh, Charles Durning, Joel Gray, Samantha Mathis, and Chris Penn.
James Nashe (Mandy Patinkin), picks up a ragged drifter by the side of the road one day.
From Rotten Tomatoes (some above, all below):